COVID-19:Europe Pushes For A Quick ,Effecient Therapy For The Disease

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Europe’s Largest Initiative Launches to Accelerate Therapy Development for COVID-19 and Future Coronavirus Threats CARE (Corona Accelerated R & D in Europe), supported by Europe’s Innovative Medicines Initiative (IMI), is the largest Enterprise of its kind working to discover and develop urgently needed treatment options for COVID-19.

The initiative is aiming to a long-term understanding of the disease and development of therapies for COVID-19 and future coronavirus threats in addition to urgent efforts to reposition existing therapies as potential immediate response.

The CARE consortium would accelerate COVID-19 R&D by bringing together the leading expertise and projects of 37 teams from academic and non-profit research institutions and pharmaceutical companies into a single comprehensive drug discovery engine.

CARE (Corona Accelerated R&D in Europe), a new consortium supported by the Innovative Medicines Initiative (IMI) public-private partnership announced its launch on Tuesday to accelerate the discovery and development of urgently needed medicines to treat SARS-CoV-2, the virus that causes COVID-19.

With a grant amounting € 77,7 million, CARE is funded by cash contributions from the European Union (EU) and cash and in-kind contributions from eleven European Federation of Pharmaceutical Industries and Associations (EFPIA) companies and three IMI-Associated Partners.

CARE is a five-year project regrouping 37 partners from Belgium, China, Denmark, France, Germany, the Netherlands, Poland, Spain, Switzerland, the UK and the US, and is under the leadership of VRI-Inserm (French National Institute of Health and Medical Research, Paris, France), Janssen Pharmaceutica NV, one of the Janssen Pharmaceutical Companies of Johnson & Johnson (Beerse, Belgium), and Takeda Pharmaceuticals International AG, (Zurich, Switzerland).

It integrates partners of COVID-19 projects ongoing since February 2020.

“The COVID-19 pandemic has emerged as the largest global health threat to humanity in this century, requiring the global scientific community to join forces in unprecedented ways,” stated Professor Yves Lévy, Executive Director of the VRI-Inserm and CARE coordinator.

"Beyond the scientific excellence of the different teams involved in this very ambitious project, CARE is bringing together 37 partners in an alliance pooling their expertise and know-how around an ambitious five-year work plan to develop therapeutics against the current COVID-19 pandemic.

He continued:"we are very grateful for the financial support provided by the Innovative Medicine Initiative that will enable us to implement this plan.

” With no licensed vaccines and only limited therapy options against COVID-19, the pandemic is ongoing, counting more cases and deaths every day.

"Grouping some of the most innovative and experienced scientists from all relevant areas in a unique collaborative spirit CARE will maximize synergies and complementarities with other initiatives such as the Gates Foundation-supported COVID-19 Therapeutics Accelerator, MANCO1, SCORE2, and the ECRAID3 network, to accelerate the path to providing solutions for the current COVID-19 pandemic as well as future coronavirus outbreaks", he said.

After testing in the laboratory, the project will submit the most promising drug candidates to clinical trials in humans.

“We are very excited to launch the CARE consortium and collaborate with other leading experts to urgently identify new medicines against SARS-CoV-2 and other coronaviruses that may have the potential to cause epidemics,” indicated CARE project leader Marnix Van Loock, Senior Scientific Director and R&D Lead of Emerging Pathogens, Global Public Health, Janssen Pharmaceutica NV.

“As part of this initiative, we look forward to applying learnings from an ongoing collaboration on COVID-19 with the Rega Institute for Medical Research, part of KU Leuven, to screen a drug repurposing library of thousands of existing drug compounds.

"COVID-19 is a once in a lifetime scientific challenge for our generation.

"CARE aims to create effective therapies with a positive safety profile for current and future coronaviral outbreaks.

"We hope to move fast and have a meaningful impact in a timely manner.

” Comprehensive short- and long-term response to COVID-19 CARE aims to create effective therapies with a positive safety profile for the COVID-19 pandemic (drug repositioning), and develop new drugs and antibodies specially designed to tackle the SARS-CoV-2 virus.

The consortium focuses on three pillars: Drug repositioning, by screening and profiling compound libraries contributed by partners with the aim of quickly progressing molecules to advanced stages of clinical testing.

Small-molecule drug discovery based on in silico screening and profiling of candidate compounds meant against SARS-CoV-2 and future coronavirus targets.

Virus neutralizing antibody discovery making fully use of human phage and yeast display, immunisation of humanised animal models, patient B cells and in silico design.

Closely integrated with these pillars are work streams directed to the refinement of candidate compounds through a comprehensive medicinal chemistry campaign, systems biology research and pre-clinical and clinical evaluation of molecules from all three pillars.

The systems biology work package woud investigate the viral pathophysiology to improve our understanding of the interplay between virus infection stages and human immune responses.


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